America has been fighting the War on Drugs for decades, but the drug cartels, the suppliers and the dealers appear to be always one step ahead of the authorities.
President Trump has declared the cartels, "terrorists" and labelled fentanyl, the powerful synthetic opioid, a "weapon of mass destruction".
But the drug supply is changing, with other deadly synthetics being added to the mix, including strong animal tranquillisers, known on the streets as "tranq".
While overdose deaths are falling, the potency of the new drugs has recovery workers worried. For some the answer might lie in reducing demand, giving users support and helping them end their addiction.
BBC international correspondent Quentin Sommerville and camera journalist Darren Conway travelled to Columbus, Ohio to find out more.
Read more on this story: A wave of homemade, synthetic drugs sweeps US and deepens crisis.
Preliminary referendum results show that more than two-thirds of Alberta voters support remaining part of Canada, easing concerns over national unity.
Albertans are voting on whether to stay in Canada or pursue independence via a referendum, splitting even some close-knit families.
BBC News hears from users, dealers, prison and recovery workers as America battles with a deadly new drug epidemic.
A 16-year-old killed three children and a teacher at a primary school in Oregon before he was killed by a bystander, police say.
WATCH: The BBC's Nadine Yousif meets the separatists who want to quit the country - and the Canadians calling for unity in the face of threats from US President Trump.
The BBC's Nada Tawfik goes through new dramatic body cam footage that shows the tense moments when police arrive on scene.
Protests against sexual violence took place across more than 40 US states on 8 October.
Isaias will bring damaging winds, torrential rain and a storm surge with landfall expected late Friday.
The BBC spoke to Americans and international tourists in Washington DC about their views on the death penalty following the botched execution of Christa Pike in Tennessee.
BBC Weather's Chris Fawkes says the first hurricane of the 2026 Atlantic season could bring dangerous winds, storm surge and heavy rains to the Gulf Coast Friday.
Barack Obama awarded the Apollo 11 software engineer with the America's highest civilian honour in 2016.
Thomas Giuffra is representing a woman, known in legal documents as Jane Doe, who alleges she was raped at a frat house on campus in 2024.
The BBC's Madeline Gerber describes the conditions of the mansion where the children - some as young as two months old - were living.
The US death row inmate's legal team said at a press conference that she is now "conscious and speaking" after her failed execution.
The BBC's Sarah Smith details the injuries sustained by the US death row inmate after two failed lethal injections, and what comes next.
The BBC's Samira Hussain explains the impact the $110bn merger will have on consumers of both entertainment giants.
Canada's Parti Québécois has promised it will hold the province's third vote on independence, but said they won’t do so until Donald Trump is out of office.
The White House said Trump was warning of the risk a nuclear Iran with his comments at a Nebraska rally.
The Pentagon confirmed on Sunday it had removed its bombers - thought to be about a dozen B-1s - from the base back to their home stations in America.
The bodycam footage also shows a police officer finding a gun in Mangione's backpack, days after the killing of UnitedHealthcare CEO Brian Thompson.
