Pope Leo XIV has been diagnosed with lung cancer but had successful surgery to remove a lower lobe of his right lung, the Vatican has said in a medical bulletin.
The 71-year-old underwent a 90 minute surgery on Tuesday at Rome's Gemelli Hospital and was subsequently diagnosed with lung adenocarcinoma.
"After the operation, the Pope awoke normally and returned after a brief period of observation to his room on the 10th floor," the Vatican said in a statement.
The lump was first detected during what the Vatican has described as "routine checks".
Earlier, large crowds gathered outside the hospital to greet the Pope, with some waiting for several hours.
They cheered greetings and well wishes as he passed, while he waved and smiled back through the lowered back window of his car.
He was then met by staff on the hospital steps. "I'm sorry," one of them commiserated, to which the Pope gave a smile and a shrug. "We're here for you," he was assured.
In its statement, the Vatican said the whole lower lobe of the Pope's right lung was removed "to ensure the procedure was radical".
A Vatican source told Agence France-Presse news agency further tests were being carried out to see if there was any sign the cancer had spread.
It was Leo XIV himself who on Sunday announced news of his operation to the world, speaking from the balcony in St Peter's Square after delivering the traditional Angelus blessing.
He said the nodule, or growth, on his lung was "contained" and had been found "at a very early stage", but that doctors had advised him to have it removed.
Gemelli's thoracic surgery team operated on the Pope, whose schedule has already been cleared until 20 October to give him time to recover.
Nodules are quite common and not necessarily cancerous, but after it was examined the medical team confirmed it was pulmonary adenocarcinoma, "as suspected by pre-operative tests", the Vatican said.
The Vatican has stressed that the pontiff, who is generally thought to be fit, had no symptoms of infection or illness.
Cardinal Kikuchi Tarcisio Isao of Tokyo wrote on social media that he'd had an audience with Pope Leo on Monday, and said the pontiff felt "nothing wrong" physically.
He said the Pope had decided to check in for surgery as soon as possible because he was due to travel to Latin America in early November, and was keen to stick to that plan.
The trip is particularly significant because it includes a visit to Peru, where the pontiff was a missionary and then a Bishop for many years.
Despite all the reassurances, the news has shaken Catholics all over the world.
"Am I worried? Yes, because I certainly wasn't expecting anything like this," Vatican Secretary of State Cardinal Parolin told journalists on Tuesday.
He agreed that the news was like a "bolt from the blue", but said the cardinals had been struck by the Pope's "serenity" and were confident in his recovery.
Outside Gemelli Hospital, which has treated several popes and is home to a large statue of John Paul II, a few Catholics lingered after the pontiff was admitted.
Carla had come specially, wanting to be close.
"He seems calm, so we are calm too - even though illness is always unpleasant," she told the BBC. "We will wait here and pray."
"I was in St Peter's Square when he made the announcement, and I felt really awful," said Elsa, who was also present. "I was really taken aback," she said, explaining that when Pope Leo was elected she had thought he was a younger, healthier pontiff.
"It turns out he's vulnerable too," she added.
